Products
Online Inquiry
BMS-345541
Cat. No.:
OB0225WX-2727
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
BMS-345541 is a highly selective inhibitor of IKK catalytic subunits, demonstrating IC50 values of 0.3 micromolar for IKK-2 and 4 micromolar for IKK-1 in biochemical assays.
Synonym:
445430-58-0; BMS-345541 free base; IKK Inhibitor III, BMS-345541; BMS345541; N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine; IKK Inhibitor III; 1,2-Ethanediamine, N-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-; N'-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine; 1,2-Ethanediamine, N1-(1,8-dimethylimidazo(1,2-a)quinoxalin-4-yl)-; BMS-345541(free base); BMS-345541 (free base); 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a) quinoxaline; N-(2-aminoethyl)-1,8-dimethylimidazo[1,2-a]quinoxalin-4-amine; N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine
CAS No.:
445430-58-0
Compound CID:
9813758
Formula:
C14H17N5
Formula Weight:
255.32
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
BMS-345541 is utilized in signal transduction research as a highly selective inhibitor of the IKK complex to investigate the disruption of NF-kappaB activation and its role in regulating inflammatory gene expression.
Library Information
Target:
IκB/IKK
Receptor:
IKK1; IKK2
Pathways:
NF-κB
Plate Number:
L6700-09
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
9 mg/mL; 35.25 mM
Water Max Solubility:
58 mg/mL
ALogP:
1.472
HBA_Count:
2
HBD_Count:
2
Rotatable Bond:
3
