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cKK-E15
Cat. No.:
OB0626WX-3825
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR and TLC.
Size:
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Product Overview
Description:
cKK-E15 is an ultra-efficient ionizable cationic lipid synthesized as a structurally optimized core analogue of the cKK-E12 framework for lipid nanoparticle engineering. This unique core matrix drives high-level protein translation across diverse hepatic cell types, including Kupffer cells, endothelial borders, and parenchymal hepatocytes; notably, its intracellular delivery mechanics operate via an advanced, ApoE-independent and Ldlr-independent transport pathway that maintains robust transfection during localized inflammation.
Synonyms:
3,6-bis[4-[bis(2-hydroxypentadecyl)amino]butyl]-2,5-piperazinedione; 1432494-71-7
CAS No.:
1432494-71-7
Compound CID:
89534839
Formula:
C72H144N4O6
Formula Weight:
1161.9
Specification
Solubility in Ethanol:
10 mg/mL
Storage:
Storage at -20°C.
Applications:
cKK-E15 serves as a synthetic lipid-like material for investigating nucleic acid delivery and lipid nanoparticle formulation strategies. It supports formulation optimization, structure–activity relationship studies, and evaluation of lipid-mediated delivery performance in preclinical research.
