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C12-TLRa
Cat. No.:
OB0626WX-3725
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
C12-TLRa is a multi-functional adjuvant lipidoid possessing an apparent pKa of 6.42 and intrinsic Toll-like receptor 7/8 agonist activity. When integrated into lipid nanoparticles as a structural substitute for conventional lipidoids, this molecule provides concurrent adjuvant signaling to stimulate pro-inflammatory cytokine pathways. This dual-action matrix improves the efficiency and duration of transcript translation, accelerates dendritic cell maturation, and triggers superior antigen-specific B cell expansion within lymphoid networks.
Synonyms:
1,1'-((4-((4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl)benzyl)azanediyl)bis(dodecan-2-ol); C12-Toll-Like Receptor a; 3067466-15-0
CAS No.:
3067466-15-0
Compound CID:
168475938
Formula:
C46H73N5O2
Formula Weight:
728.1
Specification
Solubility in DMSO:
1-10 mg/mL
Solubility in Other Solvents:
Chloroform: 0.1-1 mg/mL; Methanol: 0.1-1 mg/mL
Storage:
Storage at -20°C.
Applications:
C12-TLRa is utilized in lipid and immunological research as a functional lipid component for investigating lipid-associated recognition and formulation strategies. It supports studies involving lipid structure analysis, molecular interactions, and lipid-based research platforms.