AKT inhibitor VIII

Cat. No.: OB0225WX-1634

Appearance: Solid

Purity: ≥98%

Identity: Confirmed by NMR.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: AKT inhibitor VIII is an isoform-specific inhibitor of Akt1 and Akt2 (IC50: 58 nM and 210 nM), demonstrating a 36-fold higher selectivity for Akt1 compared to the Akt3 subtype.

Synonym: AKTi-1/2; 612847-09-3; Akt-I 1,2; 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; 1-(1-(4-(6-Phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)-piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 3-[1-[[4-(7-phenyl-3H-imidazo[4,5-g]quinoxalin-6-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one; 1-(1-(4-(7-Phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2; 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; 1-(1-((4-(7-Phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)phenyl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-{1-[(4-{6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl}phenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one; 3-[1-[[4-(6-phenyl-8H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]piperidin-4-yl]-1H-benzimidazol-2-one; Akti-1-2 compound; Akt-I-1,2 compound; isozyme-selective, Akti-1/2; 1-(1-(4-(6-Phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one; 1,3-Dihydro-1-[1-[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenylmethyl]-4-piperidinyl]-2H-benzimidazol-2-one; 1-(1-(4-(7-Phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one; 1-(1-(phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-yl}phenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one; 1-{1-[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one

CAS No.: 612847-09-3

Compound CID: 135398501

Formula: C₃₄H₂₉N₇

Formula Weight: 551.64

Specification

Targets&IC50: Akt1: 58 nM; Akt2: 210 nM

Relative Density: 1.351 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: AKT inhibitor VIII is used as a specific chemical probe in laboratory studies to explore the selective allosteric inhibition of Akt1 and Akt2 and its impact on cell cycle progression.