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AdipoUpX™ Human PPARG AAV Particle (Overexpression)
Cat. No.:
V1125XX16
Species:
Human
Target Gene:
PPARG
Vector System:
AAV
SPECIFIC INQUIRY
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| Sub Cat. No. | AAV Serotype | Tissue Tropism | Inquiry |
|---|---|---|---|
| V1125XX16-1 | AAV1 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Skeletal muscle; Smooth muscle | Inquiry |
| V1125XX16-2 | AAV2 | CNS; Brain; Retina; Inner ear; Kidney; Testes; Liver; Pancreas; Smooth muscle | Inquiry |
| V1125XX16-3 | AAV3 | Lung; Liver; Smooth muscle | Inquiry |
| V1125XX16-4 | AAV4 | CNS; Retina; Heart; Lung; Kidney | Inquiry |
| V1125XX16-5 | AAV5 | CNS; Brain; Retina; Heart; Lung; Smooth muscle | Inquiry |
| V1125XX16-6 | AAV6 | Heart; Lung; Liver; Pancreas; Adipose; Smooth muscle | Inquiry |
| V1125XX16-7 | AAV7 | CNS; Brain; Retina; Liver; Smooth muscle | Inquiry |
| V1125XX16-8 | AAV8 | CNS; Brain; Retina; Inner ear; Heart; Liver; Pancreas; Kidney; Adipose; Smooth muscle | Inquiry |
| V1125XX16-9 | AAV9 | CNS; Brain; Retina; Inner ear; Heart; Lung; Liver; Pancreas; Kidney; Testes; Adipose; Skeletal muscle; Smooth muscle | Inquiry |
| V1125XX16-10 | Other | Inquiry |
Product Overview
Description:
AdipoUpX™ Human PPARG AAV Particle (Overexpression) is a ready-to-use gene delivery tool that has undergone rigorous quality control. It is specifically designed for the rapid, efficient, and stable overexpression of the human PPARG gene in mammalian cells. As the master regulator of adipocyte differentiation and insulin sensitization, this AAV particle is a reliable and powerful asset for in-depth research into Type 2 Diabetes, obesity, and lipid metabolism. Our AAV platform offers the benefit of high customization, allowing clients to flexibly select from multiple AAV serotypes, cell-specific promoters, and fluorescent reporter genes for precise targeted delivery and multifunctional tracking validation.
Production Cell Line:
HEK293
AAV ITR:
AAV2 ITR
Promoter:
CMV (default); Other universal or cell-specific promoters
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Vector genome integrity for all preparations was successfully confirmed by PCR validation.
Sterility Test:
The QC assay verified the sterility of this product lot.
Mycoplasma Test:
The product was confirmed free of mycoplasma contamination after being subjected to stringent quality control testing.
Other QC:
Based on specific project requirements, we provide customized supplementary testing and conduct in vivo and in vitro transduction assessments to thoroughly analyze transgene expression levels and biological functions.
Storage:
Following receipt, immediate transfer to a -80°C is essential to maintain product integrity.
Stability:
Excellent stability for 6-12 months is guaranteed when the product is stored consistently at -80°C, a period which can extend up to 2 years. The thawed working solution is stable for 2-3 weeks at 4°C.
Shipping Condition:
Our AAV viral products are shipped using dry ice.
Handling Notes:
To maintain titer and prevent the damaging effects of repeated freeze-thaw cycles, it is recommended that the vector be aliquoted into low-protein-binding tubes immediately upon receipt; remember to perform all necessary operations inside a biosafety cabinet.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements throughout all operational processes. While our company commits to product quality via rigorous internal QC inspections, we do not guarantee product performance or experimental results in any specific application due to diverse and complex conditions.
Target Profile
Gene Name:
PPARG
Full Name:
Peroxisome proliferator activated receptor gamma
Gene Symbol:
GLM1; CIMT1; FPLD3; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma
Gene ID:
5468
RefSeq ID:
NM_005037.5, NP_005028.4
Summary:
The PPARG gene encodes the peroxisome proliferator-activated receptor gamma, a protein that serves as a central hub for transcriptional regulation within the cell nucleus. PPAR gamma does not act alone but must form heterodimers with the retinoid X receptor (RXR) to bind DNA and initiate transcription of downstream genes. This mechanism positions it as a molecular driver in adipocyte differentiation. Due to its extensive influence on lipid and glucose metabolism, dysregulation of PPARG activity is considered a core driver in the pathophysiology of obesity, diabetes, atherosclerosis, and even certain types of cancer.
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