AdipoUpX™ Human PHIP MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human PHIP MSCV Particle (Overexpression) is a high-titer MSCV particle designed for the specific and efficient stable expression of the human PHIP gene. PHIP is an essential mediator of the insulin receptor pathway and POMC-mediated satiety. The MSCV vector is optimized for high-level expression in stem cells, hematopoietic stem cells, etc., making it an ideal asset for longitudinal studies in obesity genetics. This product supports flexible reporter gene customization and undergoes exhaustive quality control screening to ensure experimental safety and high-fidelity results.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: PHIP

Full Name: PHIP subunit of CUL4-Ring ligase complex

Gene Symbol: ndrp; BRWD2; DIDOD; RepID; WDR11; DCAF14; CHUJANS

Gene ID: 55023

RefSeq ID-1: NP_060404.4

RefSeq ID-2: NM_017934.6

Summary: PHIP produces a protein involved in insulin signaling through its interaction with insulin receptor substrate 1. In skeletal muscle cells, PHIP contributes to the regulation of glucose transporter translocation, thereby influencing glucose uptake. The protein has also been implicated in pancreatic beta-cell maintenance and survival. Beyond metabolic regulation, increased PHIP gene copy number and expression have been correlated with melanoma progression, indicating a broader role in cell proliferation and metastatic potential.

AdipoUpX™ Human PHIP MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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