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AdipoUpX™ Human MAPK14 MSCV Particle (Overexpression)

Cat. No.: V1225XX810
Species: Human
Target Gene: MAPK14
Vector System: MSCV Retrovirus
Modulation Type: Overexpression
AdipoUpX™ Human MAPK14 MSCV Particle (Overexpression)
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Mammalian Cell Selection:
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Titer:
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Product Overview

Description: AdipoUpX™ Human MAPK14 MSCV Particle (Overexpression) is a high-titer, ready-to-use MSCV retroviral particle professionally engineered for the stable overexpression of the human MAPK14 gene. This kinase is a major driver of thermogenesis and stress responses in adipose tissue. The MSCV backbone is optimized for hematopoietic stem cells, stem cells, etc., ensuring high-level, stable integration for consistent signaling analysis. Product quality is ensured by rigorous purification and comprehensive quality control screening against various contaminants to guarantee reliable outcomes.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test: No microbial contamination was detected in any product.
Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition: Our MSCV retroviral products are shipped using dry ice.
Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: MAPK14
Full Name: Mitogen-activated protein kinase 14
Gene Symbol: RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA
Gene ID: 1432
RefSeq ID-1: NP_001306.1
RefSeq ID-2: NM_001315.3
Summary: MAPK14 encodes a stress-activated mitogen-activated protein kinase that integrates inflammatory and environmental signals to regulate fundamental cellular processes. Activation of MAPK14 occurs through phosphorylation by MAP kinase kinases or via TAB1-mediated autophosphorylation in response to pro-inflammatory cytokines and cellular stress. The kinase phosphorylates substrates including ATF2, MEF2C, MAX, CDC25B, and p53, linking MAPK14 signaling to transcriptional regulation, cell cycle control, and genotoxic stress responses. Multiple alternatively spliced transcript variants of MAPK14 produce distinct isoforms with potentially diverse regulatory functions.

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