Product Overview
Description:
AdipoUpX™ Human G6PC1 MSCV Particle (Overexpression) is a high-efficiency retroviral vector designed to stably overexpress the human G6PC1 gene. G6PC1 is a key enzyme in gluconeogenesis and glucose homeostasis, central to systemic metabolic regulation. The MSCV backbone supports durable expression in hematopoietic stem cells, stem cells, and other mammalian systems. Comprehensive QC ensures reproducibility and experimental safety.
Production Cell Line:
HEK293T
Promoter:
Ubi; CMV; EF1a; Others
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test:
No microbial contamination was detected in any product.
Mycoplasma Test:
No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC:
Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage:
The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability:
Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition:
Our MSCV retroviral products are shipped using dry ice.
Handling Notes:
Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.
Target Profile
Gene Name:
G6PC1
Full Name:
Glucose-6-phosphatase catalytic subunit 1
Gene Symbol:
G6PC; G6PT; GSD1; GSD1a; G6Pase
Summary:
G6PC1 encodes the catalytic component of the glucose-6-phosphatase system located in the endoplasmic reticulum. This enzyme catalyzes the final step of gluconeogenesis and glycogenolysis by converting glucose-6-phosphate into glucose and inorganic phosphate, making it essential for systemic glucose balance. Mutations in G6PC1 impair glucose output from the liver and kidney and result in glycogen storage disease type I (von Gierke disease), characterized by severe fasting hypoglycemia and metabolic dysregulation.
