Products
Online Inquiry
AD80
Cat. No.:
0225LY-0801
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
AD80 is a multikinase inhibitor that primarily targets S6K, SRC, RAF, and RET, while showing significantly diminished activity against mTOR.
Synonym:
1384071-99-1; 1-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea; 3-(4-{4-amino-1-isopropylpyrazolo[3,4-d]pyrimidin-3-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea
CAS No.:
1384071-99-1
Compound CID:
71578106
Formula:
C22H19F4N7
Formula Weight:
473.43
Specification
Targets&IC50:
RET (V804L): 0.6 nM; RET (V804M): 0.4 nM
Relative Density:
1.49 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AD80 can be used in oncology research to investigate the simultaneous inhibition of RET, RAF, and SRC kinases.
Library Information
Target:
S6 Kinase; c-RET; Raf; Src
Receptor:
Raf; RET V804L; RET V804M; RSK; S6 Kinase; Src
Pathways:
Apoptosis; PI3K/Akt/mTOR signaling; Angiogenesis; MAPK; Tyrosine kinase/adaptors
Plate Number:
AOCL-11
Plate Location:
c10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 126.73 mM
