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Acitretin-d3
Cat. No.:
OB0626WX-1360
Appearance:
Solid
Purity:
≥99% (deuterated forms, d1-d3)
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
Acitretin-d3 functions as a highly stable, deuterated internal standard engineered for the precise mass spectrometric quantification of native acitretin. The unlabeled retinoid is a pharmacologically active metabolite of etretinate that displays potent antiproliferative properties. It selectively binds to cellular retinoic acid binding proteins while exhibiting low affinity for retinoic acid receptor-retinoid X receptor heterocomplexes. Additionally, it suppresses pro-inflammatory signaling pathways, including downstream regulators like STAT1 and NF-κB, and mitigates psoriatic skin lesions in vivo.
Labeling:
Stable isotope-labeled
Synonyms:
(2E,4E,6E,8E)-9-(4-(methoxy-d3)-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
Formula:
C21H23D3O3
Formula Weight:
329.5
Specification
Storage:
Storage at -20°C.
Applications:
Acitretin-d3 functions as a deuterated stable isotope internal standard optimized for precision mass spectrometry profiling, enabling high-accuracy tracking of retinoid transport mechanics, metabolic degradation pathways, and receptor-ligand interaction dynamics.
