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2H-Cho-Arg, trifluoroacetate salt
Cat. No.:
OB0626WX-3978
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and IR.
Size:
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Product Overview
Description:
2H-Cho-Arg is an arginine-modified steroid-based cationic lipid containing a saturated 2H-cholesterol core coupled to a basic amino acid headgroup. This molecule neutralizes the negative backbone of plasmid vectors to restrict electrophoretic mobility, driving intracellular gene transport via specialized lipid-raft and caveolae-mediated entry pathways rather than classical clathrin routes.
Synonyms:
(3β)-[6-[[(2S)-2-amino-(5α)-[(aminoiminomethyl)amino]-1-oxopentyl]amino]hexanoate], cholestan-3-ol, bis(2,2,2-trifluoroacetate); 1609010-59-4; (3beta)-[6-[[(2S)-2-amino-(5alpha)-[(aminoiminomethyl)amino]-1-oxopentyl]amino]hexanoate],cholestan-3-ol,bis(2,2,2-trifluoroacetate); [(4S)-4-azaniumyl-5-[[6-[[(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-oxohexyl]amino]-5-oxopentyl]-(diaminomethylidene)azanium;2,2,2-trifluoroacetate
CAS No.:
1609010-59-4
Compound CID:
137700523
Formula:
C39H73N5O3 • 2CF3COO
Formula Weight:
886.1
Specification
Solubility in DMSO:
50 mg/mL
Solubility in Ethanol:
50 mg/mL
Solubility in DMF:
50 mg/mL
Solubility in Other Solvents:
Ethanol:PBS mixture: 0.25 mg/mL
Storage:
Storage at -20°C.
Applications:
2H-Cho-Arg, trifluoroacetate salt serves as a cholesterol-derived conjugate for investigating lipid-mediated delivery approaches and membrane-associated interactions. It supports formulation studies, characterization of synthetic lipid conjugates, and evaluation of lipid-based carrier systems.