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1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride)
Cat. No.:
OB0626WX-3891
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, IR, and HPLC.
Size:
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Product Overview
Description:
1,2-Dioleoyl-3(S)-trimethylammoniumpropane is an enantiopure cationic lipid featuring an exact (S)-stereochemical configuration, serving as the less immunologically active chiral isomer of the DOTAP matrix. This structurally defined lipid compresses polyanionic oligonucleotides into functional lipoplexes that downregulate target steroidogenic enzymes in carcinoma lines and mediate tumor volume mitigation without inducing strong local interferon-driven T cell responses.
Synonyms:
N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-1-propanaminium, monochloride; (S)-DOTAP; (S)-N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium; 428506-51-8
CAS No.:
428506-51-8
Compound CID:
11578450
Formula:
C42H80NO4 • Cl
Formula Weight:
698.5
Specification
Solubility in Ethanol:
20 mg/mL
Storage:
Storage at -20°C.
Applications:
1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride) serves as a stereochemically defined cationic lipid for studies of lipid nanoparticle formulation and membrane biophysics. It supports comparative evaluation of stereoisomeric lipids, nucleic acid delivery research, liposome preparation, and characterization of cationic lipid assemblies.