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Vismodegib
Cat. No.:
0225LY-0520
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
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Product Overview
Description:
Vismodegib targets the hedgehog signaling pathway (IC50 = 3 nM) while also inhibiting transporters such as ABCG2 (IC50 = 1.4 μM) and P-gp (IC50 = 3.0 μM).
Synonym:
Erivedge; GDC-0449; RG 3616; 879085-55-9; 2-Chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide; 2-Chloro-n-[4-chloro-3-(pyridin-2-yl)phenyl]-4-methanesulfonylbenzamide; Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-
CAS No.:
879085-55-9
Compound CID:
24776445
Formula:
C19H14Cl2N2O3S
Formula Weight:
421.3
Specification
Targets&IC50:
Hedgehog: 3 nM (cell free); P-gp: 3.0 μM; ABCG2: 1.4 μM
Relative Density:
1.440 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Vismodegib can be used in developmental biology and oncology research to study the inhibition of the Hedgehog signaling pathway.
Library Information
Target:
Hedgehog/Smoothened; ABC transporter
Receptor:
Smo; ABCG2
Pathways:
GPCR/G protein signaling; Autophagy; Membrane transporter/Ion channel; Stem cell regulation
Plate Number:
AOCL-7
Plate Location:
g3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
145 mg/mL; 344.17 mM
ALogP:
4.265
HBA_Count:
4
HBD_Count:
1
Rotatable Bond:
4
