Trametinib (DMSO solvate)

Cat. No.: OB0225WX-1797

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Trametinib (DMSO solvate) is a powerful and highly selective MEK inhibitor that functions by targeting the MEK1/2 kinases with a nanomolar IC50 of 2 nM.

Synonym: Trametinib DMSO solvate; GSK-1120212 (DMSO solvate); Trametinib dimethyl sulfoxide; JTP-74057 (DMSO solvate); 1187431-43-1; Trametinib DMSO solvate; Trametinib DMSO; GSK1120212B; Mekinst; N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide compound with (methylsulfinyl)methane (1:1); DTXSID30152223; GSK1120212 (DMSO solvate); N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane; Spexotras (TN); Mekinist (TN); N-(3-(3-cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide--(methylsulfinyl)methane (1/1); N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide--(methylsulfinyl)methane (1/1); N-(3-(3-Cyclopropyl-5-((2-fluoro-4-iodophenyl)amino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido(4,3-d)pyrimidin-1(2H)-yl)phenyl)acetamide - (methylsulfinyl)methane (1:1); N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-1H,2H,3H,4H,6H,7H-pyrido[4,3-d]pyrimidin-1-yl}phenyl)acetamide; Methanesulfinylmethane

CAS No.: 1187431-43-1

Compound CID: 50992434

Formula: C₂₈H₂₉FIN₅O₅S

Formula Weight: 693.53

Specification

Targets&IC50: MEK1/2: 2 nM

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Trametinib (DMSO solvate) is utilized in molecular research as a highly selective MEK1/2 inhibitor to explore the long-term suppression of the MAPK pathway in drug-sensitive tumor models.