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TIC10
Cat. No.:
OB0225WX-1636
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
TIC10 is a small molecule that penetrates the blood-brain barrier and induces TRAIL expression via Foxo3a by simultaneously inactivating the Akt and ERK signaling pathways.
Synonym:
ONC-201; 1616632-77-9
CAS No.:
1616632-77-9
Formula:
C24H26N4
Formula Weight:
386.49
Specification
Relative Density:
1.24 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
TIC10 is applied in research focused on the induction of TRAIL-mediated apoptosis to study the combined inactivation of Akt and ERK signaling pathways.
Library Information
Target:
Akt; TNF
Receptor:
TNF receptor
Pathways:
Apoptosis; PI3K/Akt/mTOR signaling; Cytoskeletal signaling
Plate Number:
AOCL-21
Plate Location:
h11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
65 mg/mL; 168.18 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
71 mg/mL; 183.7 mM
ALogP:
3.212
HBA_Count:
2
HBD_Count:
0
Rotatable Bond:
4
