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THP1 lipid
Cat. No.:
OB0626WX-3682
Appearance:
Liquid
Purity:
≥98%
Size:
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Product Overview
Description:
THP1 lipid is an ionizable cationic lipid characterized by an apparent pKa of 5.451, engineered to serve as a high-efficiency matrix core for responsive lipid nanoparticles. This specialized architectural component drives precise nucleic acid condensation, mediating robust intracellular expression of encoded reporter proteins within both epithelial and macrophage cell networks. When co-assembled with complementary helper lipids like 1,2-POPE, the resulting particulate matrix exhibits pronounced hepatic tropism upon systemic administration, delivering significantly enhanced transfection efficiency compared to conventional standard ionizable lipid baselines and driving site-specific, recombinase-mediated genomic modification.
Synonyms:
1,2,3,6-tetrahydro-1,3-dioctyl-4,5-pyrimidinedicarboxylic acid, 4,5-diethyl ester; Tetrahydropyrimidine 1 Lipid; 3097638-13-3
CAS No.:
3097638-13-3
Formula:
C26H48N2O4
Formula Weight:
452.7
Specification
Solubility in Ethanol:
≥10 mg/mL
Storage:
Storage at -20°C.
Applications:
THP1 lipid supports lipid research involving specialized lipid components and formulation studies. It can be used to investigate lipid composition, lipid assembly characteristics, and the development of lipid-based research platforms.
