TC ASK 10

Cat. No.: OB0225WX-1771

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

Add to basket

Product Overview

Description: TC ASK 10 is an orally active and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 14 nM, showing more than 30-fold selectivity over ASK2 (IC50 = 0.51 μM).

Synonym: 1005775-56-3; ASK1 Inhibitor 10; TCASK10; 4-(1,1-dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-benzamide, dihydrochloride; 4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide;dihydrochloride; 4-tert-butyl-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride; 4-tert-butyl-N-[6-(imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride; N-(6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-tert-butylbenzamide dihydrochloride

CAS No.: 1005775-56-3

Compound CID: 68661090

Formula: C₂₁H₂₃Cl₂N₅

Formula Weight: 432.35

Specification

Targets&IC50: ASK2: 0.51 μM; ASK1: 14 nM

Relative Density: 1.31 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: TC ASK 10 is utilized in metabolic and inflammatory research as a potent ASK1 antagonist to study the reduction of ER stress and the management of high-fat diet-induced glucose intolerance.