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Tauroursodeoxycholic acid-d4, sodium salt
Cat. No.:
OB0626WX-882
Appearance:
Crystalline solid
Purity:
≥99% (deuterated forms, d1–d4)
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
Tauroursodeoxycholic acid-d4 (TUDCA-d4) is a tetra-deuterated stable isotope internal standard engineered for the absolute, mass spectrometry-based quantification of endogenous tauroursodeoxycholic acid (TUDCA) levels using GC-MS or LC-MS assays. The corresponding un-labeled analyte is a specialized taurine-conjugated form of the secondary bile acid ursodeoxycholic acid that occurs at low concentrations within human biliary secretions but is highly enriched within the bile of black bears; functionally, this hydrophilic bile acid acts as a powerful cytoprotective and neuroprotective chaperone, exhibiting robust anti-apoptotic efficacy across a variety of pre-clinical rodent models mimicking human tauopathy, Huntington's disease, acute ischemic brain injury, and degenerative retinal disorders.
Labeling:
Stable isotope-labeled
Synonyms:
2-[[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt; 3α,7β-dihydroxy-5β-cholanoyl Taurine-d4; Sodium Tauroursodeoxycholate-d4; TUDCA-d4; UR-906-d4; Tauroursodeoxycholate-d4 (sodium); Tauroursodeoxycholic Acid-d4 (sodium salt); Tauroursodeoxycholic Acid 2,2,4,4-d4 Sodium Salt; 2-[[(3a,5ss,7ss)-3,7-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic-d4 Acid Sodium Salt; Tauroursodeoxycholic acid-2,2,4,4-d4 sodium salt; 2-[[(3alpha,5beta,7beta)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]amino]-ethanesulfonic acid, monosodium salt; sodium;2-[[(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate; 2410279-95-5
CAS No.:
2410279-95-5
Compound CID:
162641834
Formula:
C26H40D4NO6S • Na
Formula Weight:
525.7
Specification
Solubility in DMSO:
20 mg/mL
Solubility in Ethanol:
1 mg/mL
Solubility in DMF:
25 mg/mL
Solubility in Other Solvents:
PBS: 1 mg/mL
Storage:
Storage at -20°C.
Applications:
Tauroursodeoxycholic acid-d4, sodium salt functions as a heavily deuterated, conjugated hydrophilic bile acid epimer tracking reference for liquid chromatography-mass spectrometry workflows, assisting in recovery determination and eliminating endogenous background baseline variables.
