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Tanzisertib
Cat. No.:
0225LY-1061
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
Tanzisertib acts as a potent inhibitor across the JNK1/2/3 isoforms (IC50: 61, 7, and 6 nM) and is studied for its potential as an antifibrotic agent.
Synonym:
CC-930; 899805-25-5
CAS No.:
899805-25-5
Formula:
C21H23F3N6O2
Formula Weight:
448.44
Specification
Targets&IC50:
JNK1: 61 nM; JNK2: 7 nM; JNK3: 6 nM
Relative Density:
1.63 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Tanzisertib can be used in clinical pharmacology to examine the efficacy of selective JNK inhibition in inflammatory and fibrotic diseases.
Library Information
Target:
JNK
Receptor:
JNK1; JNK2; JNK3
Pathways:
MAPK signaling; Inflammation; Apoptosis
Plate Number:
AOCL-14
Plate Location:
f6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 557.49 mM
Special Max Solubility:
1M HCl: 100 mg/mL; 223 mM
