Products
Online Inquiry
Taladegib
Cat. No.:
0225LY-0547
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
Taladegib acts as an orally bioavailable small molecule antagonist of the Smoothened (Smo) receptor, a surface receptor for Hedgehog ligands, and is investigated for its potential antineoplastic effects.
Synonym:
LY2940680; 1258861-20-9; 4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide Benzamide, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-
CAS No.:
1258861-20-9
Compound CID:
49848070
Formula:
C26H24F4N6O
Formula Weight:
512.5
Specification
Relative Density:
1.39 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Taladegib can be used in advanced cancer research to evaluate its potential in overcoming resistance to Hedgehog pathway inhibitors.
Library Information
Target:
Smo
Receptor:
Smo
Pathways:
Hedgehog signaling; Stem cell regulation; Developmental biology
Plate Number:
AOCL-8
Plate Location:
a11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
5.64 mg/mL; 11 mM
ALogP:
0
HBA_Count:
0
HBD_Count:
0
Rotatable Bond:
0
