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Sphingosine-1-phosphate-d7 (d18:1)
Cat. No.:
OB0626WX-1186
Appearance:
Crystalline solid
Purity:
≥99% (deuterated forms, d1-d7)
Identity:
Confirmed by IR and TLC.
Size:
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Product Overview
Description:
Sphingosine-1-phosphate-d7 is a deuterated internal standard engineered for the absolute quantification of endogenous sphingosine-1-phosphate (S1P) via advanced chromatographic mass spectrometry. The native target lipid is a bioactive lysophospholipid generated through sphingosine kinase-catalyzed phosphorylation, which is secreted to function as a vital autocrine or paracrine ligand across specific S1P receptor subtypes to drive downstream intracellular calcium mobilization and phospholipase C signaling. This signaling axis plays an indispensable role in regulating cell proliferation, angiogenesis, immune cell trafficking, and neuroprotection, whereas spatial dysregulation of its metabolic gradient is strongly implicated in chronic inflammatory and autoimmune pathologies.
Labeling:
Stable isotope-labeled
Synonyms:
(2S,3R,4E)-2-amino-4-octadecene-16,16,17,17,18,18,18-d7-1,3-diol, 1-(dihydrogen phosphate); S1P-d7 (d18:1); Sphingosine-1-Phosphoric Acid-d7; 2260670-15-1; Sphingosine-1-phosphate-d7; [(E,2S,3R)-2-amino-16,16,17,17,18,18,18-heptadeuterio-3-hydroxyoctadec-4-enyl] dihydrogen phosphate; [(E,2S,3R)-2-azaniumyl-16,16,17,17,18,18,18-heptadeuterio-3-hydroxy-octadec-4-enyl] hydrogen phosphate
CAS No.:
2260670-15-1
Compound CID:
136212727
Formula:
C18H31D7NO5P
Formula Weight:
386.5
Specification
Solubility in Other Solvents:
NaOH: 4 mg/mL
Storage:
Storage at -20°C.
Applications:
Sphingosine-1-phosphate-d7 (d18:1) serves as a stable isotope-labeled lysosphingolipid internal tracking control for high-resolution mass spectrometry, supplying an isolated heavy-mass signature that ensures quantitative calibration accuracy and corrects for matrix recovery variations during sphingolipidomic cell-signaling pathway tracing.
