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SB 202190
Cat. No.:
OB0125LY-099
Appearance:
Solid
Purity:
99.8%
Identity:
Confirmed by NMR and HPLC.
Size:
Add to basket
Product Overview
Description:
SB 202190 is a selective p38 MAPK inhibitor that regulates signaling associated with cellular stress, inflammation, and cell growth by interfering with the p38 MAPK pathway.
Synonym:
152121-30-7; FHPI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; 4-(4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)phenol; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; 4-[5-(4-Fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; 4-[4-(4-Fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol; 4-(5-(4-Fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl)phenol; 4-[4-(4-Fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one; 4-[4-(4-Fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]-1-cyclohexa-2,5-dienone
CAS No.:
152121-30-7
Compound CID:
5169
Formula:
C20H14FN3O
Formula Weight:
331.34
Specification
Targets & IC50:
p38α: 50 nM (cell free); p38β: 100 nM (cell free)
Relative Density:
1.311 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SB 202190 can be used as a research tool to explore the role of p38 MAPK activation in pathological processes.
Library Information
Targets:
Autophagy; Apoptosis; p38 MAPK
Receptors:
Apoptosis; Autophagy; p38 MAPK; p38α; p38β
Pathways:
Autophagy; Apoptosis; MAPK
Plate Number:
AOCL-7
Plate Location:
c2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
50 mg/mL; 150.9 mM
Saline Max Solubility:
3.31 mg/mL; 9.99 mM
ALogP:
4.211
HBA_Count:
2
HBD_Count:
2
Rotatable Bond:
3
