Refametinib

Cat. No.: OB0225WX-1794

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Refametinib is a highly effective and specific ATP non-competitive inhibitor of MEK1 and MEK2, yielding IC50 values of 19 nM and 47 nM, respectively.

Synonym: BAY 86-97661; BAY 869766; RDEA119; 923032-37-5; RDEA 119; RDEA-119; BAY-869766; BAY 86-9766; (S)-N-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide; BAY869766; BAY 8697661; BAY-8697661; N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide; BAY86-9766; BAY-86-9766; Refametinib (RDEA119, Bay 86-9766); BAY8697661; Cyclopropanesulfonamide, N-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-6-methoxyphenyl)-1-((2S)-2,3-dihydroxypropyl)-; (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide; N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[(2S)-2,3-dihydroxypropyl]cyclopropanesulfonamide; Refametinib (RDEA119); refametinibum; N-(3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl)-1-((2S)-2,3-dihydroxypropyl)cyclopropane-1-sulfonamide; N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide; N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide; MFCD18633256

CAS No.: 923032-37-5

Compound CID: 44182295

Formula: C₁₉H₂₀F₃IN₂O₅S

Formula Weight: 572.34

Specification

Targets&IC50: MEK2: 47 nM; MEK1: 19 nM

Relative Density: 1.82 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Refametinib is applied in metabolic and cancer research as an allosteric MEK inhibitor to study its regulatory effects on the ERK signaling axis and tumor metabolism.