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PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl), sodium salt
Cat. No.:
OB0626WX-3433
Appearance:
Lyophilized powder
Purity:
≥98%
Identity:
Confirmed by NMR.
Size:
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Product Overview
Description:
PtdIns-(3,4,5)-P3 is a multi-phosphorylated phosphatidylinositol isomer that functions as a highly specialized membrane-bound signaling scaffold, coordinating the recruitment and anchoring of cytosolic signal transduction proteins containing pleckstrin homology domains. This phosphoinositide orchestrates key intracellular architectural changes, including cytoskeletal rearrangements and vesicle-mediated membrane trafficking, through targeted protein-binding interactions. Because its polyphosphorylated headgroup is chemically resistant to cleavage by phosphoinositide-specific phospholipase C, this lipid operates fundamentally as an autonomous upstream signaling modulator rather than acting as a metabolic precursor for inositol tetraphosphates.
Synonyms:
1-(1-octadecanoyl-2R-(5Z,8Z,11Z,14Z)-eicosatetraenoylphosphatidyl)inositol-3,4,5-trisphosphate, tetrasodium salt; PI(3,4,5)P3; PI(3,4,5)P3 (18:0/20:4); PIP3[3,4,5](18:0/20:4); PIP3[3',4',5'](18:0/20:4); Phosphatidylinositol-3,4,5-triphosphate C-18 (sodium salt); SAPI-3,4,5-P3
Formula:
C47H82O22P4 • 4Na
Formula Weight:
1215
Specification
Solubility in Other Solvents:
CHCl3:CH3OH:H2O mixture: 10 mg/mL
Storage:
Storage at -20°C.
Applications:
PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl), sodium salt serves as a reference phosphoinositide compound for lipid signaling and membrane lipid studies. It supports analytical characterization, lipidomic profiling, and investigation of phosphatidylinositol phosphate species.
