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PI3Kα-IN-9
Cat. No.:
OB0225WX-1503
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
PI3Kα-IN-9 is a potent, orally active inhibitor of PI3Kα that also modulates PI3Kγ, δ, and β isoforms, characterized by its ability to suppress cell growth and trigger apoptotic pathways in malignant cells.
Synonym:
2715287-67-3; PI3Kalpha-IN-9; Compound 27 [PMID: 35834807]; 6-(4,6-Dimorpholino-1,3,5-triazin-2-yl)benzo[d]oxazol-2-amine; 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-1,3-benzoxazol-2-amine
CAS No.:
2715287-67-3
Compound CID:
164886635
Formula:
C18H21N7O3
Formula Weight:
383.4
Specification
Targets&IC50:
PI3Kδ: 146 nM; PI3Kβ: 153 nM; PI3Kα: 4.4 nM; PI3Kγ: 128 nM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
PI3Kα-IN-9 is used as a specific molecular probe in biochemical assays to study the effects of PI3K-alpha inhibition on glucose metabolism and tumor cell proliferation.
Library Information
Target:
PI3K
Receptor:
PI3Kα
Pathways:
PI3K/Akt/mTOR signaling; Apoptosis
Plate Number:
AOCL-20
Plate Location:
c7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
80 mg/mL; 208.66 mM
