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O12-D3-I3
Cat. No.:
OB0626WX-3697
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
Add to basket
Product Overview
Description:
O12-D3-I3 is a multi-functional ionizable cationic lipid with an apparent pKa of 6.39, developed to assemble high-performance lipid nanoparticles for gene-silencing applications. This ionizable core coordinates the co-encapsulation of both oligonucleotides and coordination complexes, facilitating endosomal escape to downregulate critical transcription factors or cellular transport systems in carcinoma lines. Systemically, the lipid matrix drives specific accumulation within tumor and hepatic tissue zones, supporting targeted delivery to suppress tumor growth parameters and reduce hepatocyte message levels.
Synonyms:
didodecyl 3,3'-((3-(2-amino-3-(1H-imidazol-4-yl)propanamido)propyl)azanediyl)dipropionate; 3041009-08-6
CAS No.:
3041009-08-6
Compound CID:
172872006
Formula:
C39H73N5O5
Formula Weight:
692
Specification
Solubility in Ethanol:
≥10 mg/mL
Storage:
Storage at -20°C.
Applications:
O12-D3-I3 is utilized in lipid nanoparticle research to investigate specialized lipid components and their role in formulation development. It supports studies of lipid composition optimization, nanoparticle engineering, and structure–property relationships of functional lipid materials.
