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Lurasidone hydrochloride
Cat. No.:
0225LY-0641
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
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Product Overview
Description:
Lurasidone hydrochloride serves as an atypical antipsychotic agent and thiazole derivative designed for managing bipolar disorder and schizophrenia; it functions as a partial agonist of the serotonin 5-HT1A receptor and an antagonist of the dopamine D2, serotonin 5-HT2, 5-HT7, and adrenergic alpha-2A and alpha-2C receptors.
Synonym:
Lurasidone HCl; 367514-88-3; Lurasidonhydrochloride; Lurasidone monohydrochloride; (1S,2R,6S,7R)-4-[[(1R,2R)-2-[[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl]cyclohexyl]methyl]-4-azatricyclo[5.2.1.02,6]decane-3,5-dione;hydrochloride; (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride; 4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-(((1R,2R)-2-((4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)methyl)cyclohexyl)methyl)hexahydro-, monohydrochloride, (3aR,4S,7R,7aS)-
CAS No.:
367514-88-3
Compound CID:
11237860
Formula:
C28H36N4O2S·HCl
Formula Weight:
529.14
Specification
Targets&IC50:
5-HT7: 0.495 nM; 5-HT2A: 2.03 nM; Noradrenaline α2C: 10.8 nM; D2 receptor: 1.68 nM; 5-HT1A: 6.75 nM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Lurasidone hydrochloride can be used in pharmacology to examine the antagonism of D2 and 5-HT2A receptors in psychiatric models.
Library Information
Target:
Monoamine transporter; Monoamine receptor
Receptor:
Dopamine receptor; 5-HT receptor; NE transporter
Pathways:
GPCR/G protein signaling; Neuronal signaling
Plate Number:
AOCL-9
Plate Location:
c7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
5.3 mg/mL; 10.02 mM
