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LNP GalNAc ligand 1, trifluoroacetate salt
Cat. No.:
OB0626WX-3691
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
Add to basket
Product Overview
Description:
LNP GalNAc ligand 1 is a multivalent, cluster-configured N-acetylgalactosamine derivative engineered to function as a high-affinity targeting ligand for the asialoglycoprotein receptor. The geometric presentation of the GalNAc residues mimics natural multi-antenna saccharide structures, enhancing binding avidity via localized receptor clustering. This molecular anchor is specifically integrated into the outer boundaries of lipid nanoparticles to execute precise, receptor-mediated hepatic delivery of advanced CRISPR base-editing architectures.
Synonyms:
6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-4,8-dioxa-12,16-diazaheneicosanamide, mono(2,2,2-trifluoroacetate); LNP N-Acetylgalactosamine Ligand 1 Lipid Nanoparticle; N-Acetylgalactosamine Ligand 1 Lipid Nanoparticle; GalNAc Ligand 1; Tri-GalNAc(OAc)3 TFA; Tri-GalNAc(OAc)3 (TFA); 1159408-65-7
CAS No.:
1159408-65-7
Compound CID:
162394061
Formula:
C79H128N10O36 • CF3COOH
Formula Weight:
1908
Specification
Solubility in DMSO:
1-10 mg/mL
Solubility in Ethanol:
1-10 mg/mL
Solubility in Other Solvents:
PBS: 1-10 mg/mL
Storage:
Storage at -20°C.
Applications:
LNP GalNAc ligand 1, trifluoroacetate salt is utilized in lipid nanoparticle research for investigating ligand-functionalized delivery systems and targeted lipid formulation strategies. It supports studies involving surface modification of nanoparticles, evaluation of GalNAc-based targeting approaches, and optimization of functional lipid components for nucleic acid delivery platforms.
