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Lipid compound 182
Cat. No.:
OB0626WX-3650
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
Lipid compound 182 is an ionizable cationic amine lipid displaying an apparent pKa of 6.48, engineered to facilitate pH-dependent membrane destabilization within delivery matrices. This structural lipid molecule drives efficient nucleic acid condensation to form stable lipid nanoparticles, supporting successful cellular internalization and significantly boosting systemic plasma levels of encoded target proteins following in vivo administration.
Synonyms:
8-[[3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino]propyl][8-(nonyloxy)-8-oxooctyl]amino]-octanoic acid, 1-octylnonyl ester; LNP LIPID-182; L15; Heptadecan-9-yl 8-((3-((2-(methylamino)-3,4-dioxocyclobut-1-en-1-yl)amino)propyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate; Moderna Lipid compound 182(Lipid 29 analogue-1); 1-Octylnonyl 8-[[3-[[2-(methylamino)-3,4-dioxo-1-cyclobuten-1-yl]amino] propyl] [8- (nonyloxy)-8-oxooctyl] amino]octanoate; 2089253-10-9
CAS No.:
2089253-10-9
Compound CID:
126697469
Formula:
C50H93N3O6
Formula Weight:
832.3
Specification
Solubility in Ethanol:
1-10 mg/mL
Storage:
Storage at -20°C.
Applications:
Lipid compound 182 serves as a specialized lipid component for lipid nanoparticle research. It supports formulation development, lipid assembly characterization, and investigation of novel lipid-based delivery materials.