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Leukotriene F4
Cat. No.:
OB0626WX-3288
Appearance:
Liquid
Purity:
≥97%
Identity:
Confirmed by HPLC.
Size:
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Product Overview
Description:
Leukotriene F4 is a non-canonical cysteinyl-leukotriene structure generated through the in vitro enzymatic conjugation of leukotriene E4 with glutathione via gamma-glutamyl transpeptidase machinery. Characterized by a unique amino acid configuration on its polyunsaturated fatty acid backbone, this lipid molecule acts as an attenuated agonist within vascular smooth muscle contractile hierarchies, displaying heavily blunted potency compared to native leukotrienes.
Synonyms:
5S-hydroxy-6R-(S-γ-glutamylcysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid; LTF4; 83851-42-7; Leukotriene F-4; 5S-hydroxy-6R-(S-glutamylcysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid; 5(S)-Hydroxy-6(R)-S-gamma-glutamylcysteine-7,9-trans-11,14-cis-eicosatetraenoic acid; (5S,6R,7E,9E,11Z,14Z)-6-((2R)-2-(((4S)-4-amino-4-carboxybutanoyl)amino)-2-carboxyethyl)sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid; (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-2-carboxyethyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid; L-gamma-Glutamyl-S-((1R,2E,4E,6Z,9Z)-1-((1S)-4-carboxy-1-hydroxybutyl)pentadeca-2,4,6,9-tetraen-1-yl)-L-cysteine; L-gamma-glutamyl-S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine; L-gamma-glutamyl-S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxynonadeca-6,8,10,13-tetraen-5-yl]-L-cysteine; 5S-hydroxy-6R-(S-glutamylcysteinyl)-7E,9E,11Z,14Z-eicosatetraenoate
CAS No.:
83851-42-7
Compound CID:
5280938
Formula:
C28H44N2O8S
Formula Weight:
568.7
Specification
λmax:
280 nm
Solubility in DMSO:
50 mg/mL
Solubility in Ethanol:
50 mg/mL
Solubility in DMF:
50 mg/mL
Solubility in Other Solvents:
PBS: 0.1 mg/mL
Storage:
Storage at -80°C.
Applications:
Leukotriene F4 serves as a leukotriene reference compound for cysteinyl leukotriene research and lipid mediator analysis. It supports analytical characterization, lipidomic profiling, and identification of leukotriene-related metabolites.
