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Ivabradine hydrochloride
Cat. No.:
0225LY-1169
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
Ivabradine hydrochloride is an orally available HCN channel blocker that reduces heart rate by selectively binding to pacemaker cells in the sinoatrial node, thereby inhibiting the "funny" ion current (If).
Synonym:
S 16257-2; Ivabradine HCl; 148849-67-6; Procoralan; Corlentor; Corlanor; Ivabradine (hydrochloride); (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride; 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1); (7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one hydrochloride
CAS No.:
148849-67-6
Compound CID:
3045381
Formula:
C27H37ClN2O5
Formula Weight:
505.05
Specification
Targets&IC50:
If: 2.9 μM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Ivabradine hydrochloride can be used in cardiology research to study the selective inhibition of the cardiac pacemaker if current.
Library Information
Target:
HCN channel; Adrenergic receptor
Receptor:
HCN channel; Adrenergic receptor
Pathways:
Membrane transporter/Ion channel; GPCR/G protein signaling; Neuronal signaling
Plate Number:
AOCL-16
Plate Location:
a6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 495 mM
Water Max Solubility:
75 mg/mL; 148.5 mM
Ethanol Max Solubility:
93 mg/mL; 184.14 mM
