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ISRIB (trans-isomer)
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Cat. No.:
OB0125LY-096
Size:
1 mg; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg
CAS No.:
1597403-47-8
Compound CID:
1011240
Specification
Description:
ISRIB (trans-isomer) is a potent inhibitor that regulates cellular adaptive mechanisms in response to stress.
Formula Weight:
451.34
Stability:
3 years in powder form.
Applications:
ISRIB (trans-isomer) can be used for cancer, cardiovascular and metabolic disease research.
Storage:
Storage at -20°C.
Formula:
C22H24Cl2N2O4
Appearance:
Solid
Purity:
99.2%
Identity:
Confirmed by NMR and HPLC.
Targets&IC50:
PERK: 5 nM
Relative Density:
1.33 g/cm3
Library Information
Plate Number:
AOCL-5
Plate Location:
e8
Empty Location:
a1-h1; a12-h12
Formulation:
10mM DMSO
Container:
96-well plate
Pathways:
Autophagy; Apoptosis
Targets:
Apoptosis; PERK; Autophagy
Receptors:
Apoptosis; Autophagy; PERK
DMSO Max Solubility (mg/mL):
1.11 mg/mL
DMSO Max Solubility (mM):
2.46 mM
Saline Max Solubility (mg/mL):
0.11 mg/mL
Saline Max Solubility (mM):
0.24 mM
ALogP:
4.055
HBA_Count:
4
HBD_Count:
2
Rotatable Bond:
8