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ISRIB (trans-isomer)
Cat. No.:
OB0125LY-096
Appearance:
Solid
Purity:
99.2%
Identity:
Confirmed by NMR and HPLC.
Size:
Add to basket
Product Overview
Description:
ISRIB (trans-isomer) is a potent inhibitor that regulates cellular adaptive mechanisms in response to stress.
Synonym:
1597403-47-8; ISRIB; ISRIB trans-isomer; N,N'-(cis-Cyclohexane-1,4-diyl)bis (2-(4-chlorophenoxy)acetamide); 2-(4-Chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide; N,N'-(Cyclohexane-1,4-diyl)bis (2-(4-chlorophenoxy)acetamide); Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-; 2-(4-Chlorophenoxy)-N-{4-[2-(4-chlorophenoxy)acetamido]cyclohexyl}acetamide
CAS No.:
1597403-47-8
Compound CID:
1011240
Formula:
C22H24Cl2N2O4
Formula Weight:
451.34
Specification
Targets & IC50:
PERK: 5 nM
Relative Density:
1.33 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ISRIB (trans-isomer) can be used for cancer, cardiovascular and metabolic disease research.
Library Information
Targets:
Apoptosis; PERK; Autophagy
Receptors:
Apoptosis; Autophagy; PERK
Pathways:
Autophagy; Apoptosis
Plate Number:
AOCL-5
Plate Location:
e8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
1.11 mg/mL; 2.46 mM
Saline Max Solubility:
0.11 mg/mL; 0.24 mM
ALogP:
4.055
HBA_Count:
4
HBD_Count:
2
Rotatable Bond:
8
