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Hypothemycin
Cat. No.:
OB0626WX-1466
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
Hypothemycin is a resorcylic acid lactone polyketide originally obtained from Hypomyces trichothecoides that displays broad-spectrum protein kinase inhibitory activity. It targets MEK, TAK1, and other key kinases featuring a conserved cysteine residue within their ATP-binding domains, effectively blocking downstream cascades to arrest proliferation across multiple mutation-dependent oncological lineages and suppress in vivo tumor progression.
Synonyms:
(1aR,3S,4S,6Z,9S,15bR)-1a,8,9,15b-tetrahydro-3,4,12-trihydroxy-14-methoxy-9-methyl-3H-oxireno[k][2]benzoxacyclotetradecin-5,11(2H,4H)-dione; NSC 354462; (2R,4R,6S,7S,9Z,12S)-6,7,16-trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo(13.4.0.02,4)nonadeca-1(15),9,16,18-tetraene-8,14-dione; (2R,4R,6S,7S,9Z,12S)-6,7,16-trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione; (9E)-2,3,16-trihydroxy-18-methoxy-12-methyl-6,13-dioxatricyclo(13.4.0.05,7)nonadeca-1(15),9,16,18-tetraene-8,14-dione; (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione; (1aR,8S,10Z,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione; NSC790709; NSC-790709; 76958-67-3
CAS No.:
76958-67-3
Compound CID:
9929643
Formula:
C19H22O8
Formula Weight:
378.4
Specification
Source:
Phoma sp.
λmax:
221 nm; 267 nm; 310 nm
Solubility in DMSO:
10 mg/mL
Storage:
Storage at -20°C.
Applications:
Hypothemycin acts as an isolated resorcylic acid lactone polyketide baseline standard to map target kinase-inhibitor alignment configurations, evaluate small-molecule extraction validation protocols, and analyze structural integration metrics inside model lipid domains.
