Products
Online Inquiry
Estradiol 17-(β-D-Glucuronide), sodium salt hydrate
Cat. No.:
OB0626WX-2544
Appearance:
Crystalline solid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
Add to basket
Product Overview
Description:
Estradiol 17-(β-D-glucuronide) is a biologically active, liver-derived estrogen metabolite that serves as a high-affinity substrate and allosteric modulator of multidrug resistance protein 2 (MRP2). By driving active transport across multi-specific organic anion transporter systems, this glucuronide conjugate alters normal bile flow dynamics, exhibiting positive cooperativity mechanisms that accelerate its own clearance and influence adjacent ABC transporter networks.
Synonyms:
(17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl β-D-glucopyranosiduronic acid, monosodium salt, hydrate; E217G; β-Estradiol 17-(β-D-Glucuronide); 17β-Estradiol 17-(β-D-Glucuronide); 17β-Oestradiol 17-(β-D-Glucuronide)
Formula:
C24H31O8 • Na [XH2O]
Formula Weight:
470.5
Specification
λmax:
282 nm
Solubility in DMSO:
20 mg/mL
Solubility in DMF:
10 mg/mL
Solubility in Other Solvents:
DMSO:PBS mixture: 0.5 mg/mL
Storage:
Storage at -20°C.
Applications:
Estradiol 17-(β-D-Glucuronide), sodium salt hydrate serves as a reference standard for studies of estrogen metabolism and phase II biotransformation. It supports quantitative LC-MS/MS analysis, metabolite identification, analytical calibration, and investigations of steroid glucuronidation pathways.
