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E10i-494
Cat. No.:
OB0626WX-3664
Appearance:
Liquid
Purity:
≥95% (mixture of isomers)
Identity:
Confirmed by NMR and TLC.
Size:
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Product Overview
Description:
E10i-494 is a branched ionizable cationic endosomal disruptor lipid designed to formulate responsive lipid nanoparticles for the delivery of nucleic acids and small molecules. This specialized lipid framework optimizes endosomal escape to drive robust translation of encoded reporters within T cell lines. Additionally, lipid matrices leveraging this molecule can alter the tumor immune microenvironment by successfully repolarizing tumor-associated macrophages from a suppressive state to an active M1-like phenotype, mediating a substantial reduction in tumor volume and mass within carcinoma models.
Synonyms:
1,1'-((2-(2-(4-(2-((2-(2-(bis(2-hydroxy-13-methyltetradecyl)amino)ethoxy)ethyl)(2-hydroxy-13-methyltetradecyl)amino)ethyl)piperazin-1-yl)ethoxy)ethyl)azanediyl)bis(13-methyltetradecan-2-ol); 3031773-77-7
CAS No.:
3031773-77-7
Compound CID:
175667448
Formula:
C89H183N5O7
Formula Weight:
1435.5
Specification
Solubility in Ethanol:
≥10 mg/mL
Storage:
Storage at -20°C.
Applications:
E10i-494 supports research on lipid-based delivery technologies and formulation development. It can be used for evaluating functional lipid components, investigating nanoparticle composition, and studying the relationship between lipid molecular design and delivery system characteristics.