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DSPE-PEG2000-triGalNAc
Cat. No.:
OB0626WX-4067
Appearance:
Powder
Purity:
>99%
Size:
Add to basket
Product Overview
Description:
DSPE-PEG2000-triGalNAc is an advanced, targeted pegylated lipid conjugate comprising a hydrophobic distearoylphosphatidylethanolamine anchor, a 2000-dalton polyethylene glycol spacer, and a terminal trivalent N-acetylgalactosamine (triGalNAc) targeting ligand. This engineered architecture is designed to integrate seamlessly into the lipid bilayer of nucleic acid delivery vehicles, orienting the high-affinity cluster toward the aqueous exterior to exploit receptor-mediated uptake mechanisms via asialoglycoprotein receptors.
Synonyms:
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]-N-tri(N-acetylgalactosamine), ammonium salt; DSPE-PEG2000-triGalNAc ammonium; 2936651-86-2
CAS No.:
2936651-86-2
Compound CID:
172880631
Formula:
C183H355N10O81P (average MW due to polydispersity of PEG)
Formula Weight:
4022.82
Specification
Storage:
Storage at -20°C.
Applications:
DSPE-PEG2000-triGalNAc serves as a functional PEGylated phospholipid for constructing ligand-targeted lipid nanoparticles through triGalNAc surface presentation. It supports nanoparticle functionalization, targeted delivery research, formulation optimization, and studies of ligand-directed lipid nanocarriers.
