Cot inhibitor-2

Cat. No.: OB0225WX-1773

Appearance: Solid

Purity: ≥98%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Cot inhibitor-2 is an orally active and potent inhibitor of Tpl2 (MAP3K8) with an IC50 of 1.6 nM, characterized by its ability to suppress LPS-triggered biochemical responses in whole blood.

Synonym: 915363-56-3; 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile; Wyeth Cot Inhibitor 2; 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-carbonitrile; 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl}amino)quinoline-3-carbonitrile; 8-Chloro-4-(3-chloro-4-fluoroanilino)-6-({[1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl}amino)quinoline-3-carbonitrile; 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethyl-4-piperidinyl)-4-triazolyl]methylamino]-3-quinolinecarbonitrile; 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[1-(1-ethylpiperidin-4-yl)-1,2,3-triazol-4-yl]methyl}amino)quinoline-3-carbonitrile

CAS No.: 915363-56-3

Compound CID: 44143370

Formula: C₂₆H₂₅Cl₂FN₈

Formula Weight: 539.43

Specification

Targets&IC50: Cot (Tpl2/MAP3K8): 1.6 nM; TNF-α production (human whole blood): 0.3 μM

Relative Density: 1.45 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Cot inhibitor-2 is used in molecular biology research to explore the regulatory role of Cot kinase in the ERK signaling pathway and its contribution to oncogenic transformation.