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CL4H6
Cat. No.:
OB0626WX-3912
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, IR, and HPLC.
Size:
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Product Overview
Description:
CL4H6 is an ionizable cationic lipid possessing an apparent pKa of 6.35, engineered as a multi-functional delivery vehicle for systemic nucleic acid transport. This ionizable core structure displays unique organ-tropism that preferentially directs encapsulated silencing or expression payloads into visceral tissues, tumor matrices, and tumor-associated macrophages over surrounding parenchymal cells, successfully shifting macrophage polarization states to repress tumor expansion.
Synonyms:
9-octadecenoic acid, 1,1′-[7-[4-(dipropylamino)butyl]-7-hydroxy-1,13-tridecanediyl] ester; 7-(4-(Dipropylamino)butyl)-7-hydroxytridecane-1,13-diyl dioleate; [7-[4-(dipropylamino)butyl]-7-hydroxy-13-[(Z)-octadec-9-enoyl]oxytridecyl] (Z)-octadec-9-enoate; 2256087-35-9
CAS No.:
2256087-35-9
Compound CID:
146593563
Formula:
C59H113NO5
Formula Weight:
916.5
Specification
Storage:
Storage at -20°C.
Applications:
CL4H6 serves as an experimental ionizable lipid for lipid nanoparticle development and optimization. It facilitates investigation of lipid structure–activity relationships, formulation screening, and characterization of nucleic acid delivery systems.
