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Cholesterol-doxorubicin
Cat. No.:
OB0626WX-3884
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
Cholesterol-doxorubicin is an amphiphilic prodrug conjugate consisting of a hydrophobic cholesterol anchor linked to the anthracycline antibiotic doxorubicin. When integrated alongside amphiphilic polymer stabilizers into self-assembled nanoassemblies, this lipophilic prodrug alters typical intracellular delivery kinetics, successfully disrupting cell viability within complex breast carcinoma lineages.
Synonyms:
(3R,10R,13R,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1R,3R)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)carbamate
Formula:
C55H73NO13
Formula Weight:
956.2
Specification
Solubility in DMSO:
2 mg/mL
Solubility in DMF:
25 mg/mL
Storage:
Storage at -20°C.
Applications:
Cholesterol-doxorubicin serves as a cholesterol–drug conjugate for investigating lipid-associated drug delivery strategies and nanoparticle formulation. It supports studies of conjugate incorporation into lipid assemblies, controlled release systems, formulation optimization, and physicochemical characterization of lipid-based delivery platforms.