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CHIR 98024
Cat. No.:
0225LY-0803
Appearance:
Solid
Purity:
≥96%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
CHIR 98024 is a potent inhibitor of GSK-3 alpha and beta, with IC50 values of 0.65 nM and 0.58 nM in cell-free environments; it is notable for its ability to differentiate GSK-3 from its close homologs ERK2 and Cdc2.
Synonym:
556813-39-9; N2-(2-((4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine; 6-N-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine; CHEMBL1080901; N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine; {2-[(6-amino-5-nitro(2-pyridyl))amino]ethyl}[4-(2,4-dichlorophenyl)-5-imidazolyl-pyrimidin-2-yl]amine
CAS No.:
556813-39-9
Compound CID:
9957049
Formula:
C20H17Cl2N9O2
Formula Weight:
486.31
Specification
Targets&IC50:
GSK-3α: 0.65 nM; GSK-3β: 0.58 nM
Relative Density:
1.573 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
CHIR 98024 can be used in cell biology research, particularly in the study of GSK-3 signaling and its role in cellular development.
Library Information
Target:
GSK-3; S6 Kinase
Receptor:
GSK-3α/β; p70 S6K
Pathways:
MAPK; Stem cell regulation; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-11
Plate Location:
d2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
6.88 mg/mL; 14.15 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
