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Aprepitant
Cat. No.:
0225LY-0983
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
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Product Overview
Description:
Aprepitant functions as a neurokinin 1 (NK1) receptor antagonist and also acts as a modulator of cytochrome P450 enzymes, specifically inhibiting 3A4 while inducing 2C9.
Synonym:
MK-869; MK-0869; L-754030; Aprepitant`; 170729-80-3; Emend; Aponvie; Cinvanti; Aprepitantum; MK 0869; 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one; 5-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,3-dihydro-1H-1,2,4-triazol-3-one
CAS No.:
170729-80-3
Compound CID:
135413536
Formula:
C23H21F7N4O3
Formula Weight:
534.43
Specification
Targets&IC50:
NK1 receptor: 0.1 nM
Relative Density:
1.51 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Aprepitant can be used in pharmacological studies to investigate the blockade of substance P at the NK1 receptor.
Library Information
Target:
HIV protease; Neurokinin receptor
Receptor:
HIV protease; NK1 receptor
Pathways:
Neuronal signaling; Proteases/Proteasome; Microbiology/Virology; GPCR/G protein signaling
Plate Number:
AOCL-13
Plate Location:
f5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
104 mg/mL; 194.6 mM
Ethanol Max Solubility:
12 mg/mL; 22.45 mM
