AdipoUpX™ Human PYY MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human PYY MSCV Particle (Overexpression) is a powerful gene delivery tool designed for the stable overexpression of the human PYY gene. As a significant gut-derived satiety signal, PYY is essential for research into the hormonal regulation of appetite. The MSCV vector is optimized for hematopoietic and stem cell types, etc., ensuring reliable and high-level gene integration for functional validation in diverse cellular environments. Product quality is ensured by rigorous purification and comprehensive QC screening to provide a safe and repeatable research asset.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: PYY

Full Name: Peptide YY

Gene Symbol: PYY1; PYY-I

Gene ID: 5697

RefSeq ID-1: NP_001380957.1

RefSeq ID-2: NM_001394028.1

Summary: PYY is the precursor for a neuropeptide Y (NPY) family member, synthesized and secreted by gut endocrine cells, primarily in response to food intake. The preproprotein is cleaved to produce two bioactive forms (PYY (1-36) and PYY (3-36)), which signal through various NPY receptors. These circulating peptides function as a potent satiety signal, suppressing appetite and regulating gastrointestinal motility and pancreatic secretion, thereby ensuring energy homeostasis. Fluctuations or rare variations in the PYY gene have been associated with both increased obesity susceptibility and, conversely, elevated levels are seen in patients with anorexia nervosa.

AdipoUpX™ Human PYY MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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