AdipoUpX™ Human IKBKB MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human IKBKB MSCV Particle (Overexpression) is engineered for stable expression of the human IKBKB gene, a central kinase in NF-κB signaling. IKBKB-mediated inflammatory pathways are closely linked to insulin resistance and obesity-related metabolic inflammation. The MSCV system ensures durable gene expression in stem cells and multiple mammalian cell models. Comprehensive quality control ensures reproducibility and biosafety.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: IKBKB

Full Name: Inhibitor of nuclear factor kappa B kinase subunit beta

Gene Symbol: IKK2; IKKB; IKK-2; IMD15; IMD15A; IMD15B; NFKBIKB; IKK-beta

Gene ID: 3551

RefSeq ID-1: NP_001177649.1

RefSeq ID-2: NM_001190720.2

Summary: IKBKB encodes a core kinase of the NF-κB signaling pathway that activates inflammatory gene expression by releasing NF-κB from its inhibitors. Chronic activation of this pathway contributes to low-grade inflammation observed in obesity. Through integration of inflammatory and metabolic signals, IKBKB plays a central role in obesity-associated insulin resistance. Multiple coding and noncoding transcript variants exist.

AdipoUpX™ Human IKBKB MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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