Products
Online Inquiry
AA3-DLin
Cat. No.:
OB0626WX-3901
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and IR.
Size:
Add to basket
Product Overview
Description:
AA3-DLin is an ionizable cationic amino lipid characterized by an apparent pKa of 5.8, engineered for integration into multicomponent lipid nanoparticles designed for non-viral immunization. The specific ionization threshold enables stable transcript encapsulation and low-pH membrane fusion, driving targeted cellular uptake and high-level translation of viral surface proteins to trigger potent downstream immunogenicity.
Synonyms:
Piperazine-1,4-diylbis(ethane-2,1-diyl) (9Z,9'Z,12Z,12'Z)-bis(octadeca-9,12-dienoate); Piperazine-bis(ethyl octadeca-9,12-dienoate); 2832061-33-1; Piperazine-1,4-diylbis(ethane-2,1-diyl) (9E,9'E,12E,12'E)-bis(octadeca-9,12-dienoate)
CAS No.:
3027565-91-6
Compound CID:
168355618
Formula:
C44H78N2O4
Formula Weight:
699.1
Specification
Solubility in Ethanol:
25 mg/mL
Storage:
Storage at -20°C.
Applications:
AA3-DLin serves as a synthetic ionizable lipid for the development of lipid nanoparticle delivery systems. It supports formulation optimization, physicochemical characterization, and structure–activity relationship studies aimed at improving nucleic acid delivery efficiency.