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8-iso PGE2-d4
Cat. No.:
OB0626WX-2860
Appearance:
Liquid
Purity:
≥99% (deuterated forms, d1–d4)
Identity:
Confirmed by TLC and HPLC.
Size:
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Product Overview
Description:
8-iso PGE2-d4 is a stable isotope-labeled, tetradeuterated analogue designed for the precise quantitative indexing of native 8-iso prostaglandin E2 via chromatography-mass spectrometry. The non-labeled eicosanoid intermediate is generated during free radical-catalyzed lipid peroxidation cascades and acts as a potent vasoactive mediator capable of downregulating platelet aggregation pathways and altering renal hemodynamics by reducing glomerular filtration rate and plasma flow.
Labeling:
Stable isotope-labeled
Synonyms:
9-oxo-11α,15S-dihydroxy-(8β)-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid; 8-epi PGE2-d4; 8-iso Prostaglandin E2-d4
Formula:
C20H28D4O5
Formula Weight:
356.5
Specification
Solubility in DMSO:
>100 mg/mL
Solubility in Ethanol:
>100 mg/mL
Solubility in DMF:
>100 mg/mL
Solubility in Other Solvents:
PBS: >5 mg/mL
Storage:
Storage at -20°C.
Applications:
8-iso PGE2-d4 serves as a stable isotope-labeled reference standard for oxidized lipid mediator analysis. It supports quantitative lipidomics, isotope dilution analysis, analytical calibration, and characterization of prostaglandin-related metabolites.
