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6’,7’-Epoxybergamottin
Cat. No.:
OB0626WX-2364
Appearance:
Crystalline solid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
6’,7’-Epoxybergamottin is a naturally occurring furanocoumarin isolated from grapefruit matrices that functions as a potent inhibitor of the cytochrome P450 enzyme isoform CYP3A4. This bioactive molecule modulates xenobiotic processing pathways and alters cellular drug transport across epithelial monolayers by interfering with permeability glycoprotein (P-gp/ABCB1) transporter dynamics.
Synonyms:
4-[[(2E)-5-(3,3-dimethyl-2-oxiranyl)-3-methyl-2-penten-1-yl]oxy]-7H-furo[3,2-g][1]benzopyran-7-one; Epoxybergamottin; 4-[(E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enoxy]furo[3,2-g]chromen-7-one; 4-((E)-5-(3,3-dimethyloxiran-2-yl)-3-methylpent-2-enoxy)furo(3,2-g)chromen-7-one; 206978-14-5
CAS No.:
206978-14-5
Compound CID:
9946625
Formula:
C21H22O5
Formula Weight:
354.4
Specification
λmax:
251 nm; 311 nm
Solubility in DMSO:
30 mg/mL
Solubility in DMF:
30 mg/mL
Solubility in Other Solvents:
DMSO:PBS mixture: 0.5 mg/mL
Storage:
Storage at -20°C.
Applications:
6’,7’-Epoxybergamottin serves as a reference compound for furanocoumarin analysis and natural product metabolism research. It supports analytical characterization, LC-MS/MS-based metabolite profiling, chromatographic method development, and investigations of plant secondary metabolites and metabolic transformation.
