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1-Stearoyl-2-arachidonoyl-d11-sn-glycero-3-PC
Cat. No.:
OB0626WX-1195
Appearance:
Liquid
Purity:
≥99% (deuterated forms, d1-d11)
Identity:
Confirmed by TLC.
Size:
Add to basket
Product Overview
Description:
1-Stearoyl-2-arachidonoyl-d11-sn-glycero-3-PC (SAPC-d11) is a site-specifically deuterated stable isotope internal standard optimized for the precise mass spectrometry quantification of native 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC). The corresponding native glycerophospholipid contains stearic acid at the sn-1 position and polyunsaturated arachidonic acid at the sn-2 position; it is an endogenous component of low-density lipoproteins (LDL) that accumulates distinctly within vascular lesions, calcified stenotic valves, and invasive regions of squamous cell carcinomas. Furthermore, synthetic unilamellar vesicles of this lipid serve as primary biochemical substrates for evaluating secretory phospholipase A2 (sPLA2) enzymatic kinetics, and its integration into model bilayers facilitates advanced studies into how lipid acyl-chain composition governs membrane phase transitions.
Labeling:
Stable isotope-labeled
Synonyms:
(R)-2-(((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl-16,16,17,17,18,18,19,19,20,20,20-d11)oxy)-3-(stearoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate; 18:0/20:4-d11-PC; PC(18:0/20:4-d11); SAPC-d11; 1-Stearoyl-2-Arachidonoyl-d11-sn-glycero-3-Phosphatidylcholine; 1-Stearoyl-2-Arachidonoyl-d11-sn-glycero-3-Phosphocholine
Formula:
C46H73D11NO8P
Formula Weight:
821.2
Specification
Solubility in Ethanol:
30 mg/mL
Solubility in Other Solvents:
Ethanol:PBS mixture: 0.3 mg/mL
Storage:
Storage at -80°C.
Applications:
1-Stearoyl-2-arachidonoyl-d11-sn-glycero-3-PC functions as a stable isotope-labeled, asymmetric mixed-acyl phosphatidylcholine incorporating a heavily deuterated polyunsaturated omega-6 tail, designed for tracing real-time lipid membrane remodeling kinetics and ensuring precise structural quantification in high-resolution lipidomic workflows.
