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SAG
Cat. No.:
0225LY-0542
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
SAG functions as a selective, cell-permeable Smo receptor agonist with an EC50 of 3 nM; it binds directly to the Smo helix to modulate its activity and trigger the Hedgehog signaling pathway.
Synonym:
912545-86-9; SAG; (Rac)-SAG; SAG Dihydrochloride; 3-Chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-yl)benzyl)benzo[b]thiophene-2-carboxamide; 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide; 3-Chloro-N-(4-(methylamino)cyclohexyl)-N-((3-(pyridin-4-yl)phenyl)methyl)-1-benzothiophene-2-carboxamide
CAS No.:
912545-86-9
Compound CID:
5284330
Formula:
C28H28ClN3OS
Formula Weight:
490.06
Specification
Targets&IC50:
Smo: 3 nM(EC50)
Relative Density:
1.30 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SAG can be used in stem cell research to act as a potent small-molecule agonist of the Smoothened receptor in the Hedgehog pathway.
Library Information
Target:
Smo
Receptor:
Smo
Pathways:
Stem cell regulation; GPCR/G protein signaling
Plate Number:
AOCL-8
Plate Location:
a6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
252.5 mg/mL; 515.24 mM
Ethanol Max Solubility:
40 mg/mL; 81.62 mM
