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ETC-159
Cat. No.:
OB0225WX-1620
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
ETC-159 is an orally available small molecule that potently inhibits PORCN, resulting in the suppression of β-catenin reporter activity with an IC50 of 2.9 nM.
Synonym:
ETC159; ETC-1922159; ETC 159; 1638250-96-0; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide; 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide; 7H-Purine-7-acetamide, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-N-(6-phenyl-3-pyridazinyl)-; 2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)-N-(6-phenylpyridazin-3-yl)acetamide
CAS No.:
1638250-96-0
Compound CID:
86280523
Formula:
C19H17N7O3
Formula Weight:
391.38
Specification
Targets&IC50:
β-catenin: 2.9 nM
Relative Density:
1.47 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ETC-159 is employed in advanced oncological research as an orally bioavailable Porcupine inhibitor to examine its efficacy in treating Wnt-dependent tumors and modulating the tumor microenvironment.
Library Information
Target:
Wnt/β-catenin; Porcupine
Receptor:
Porcn; Wnt; β-Catenin
Pathways:
Stem cells; Cytoskeletal signaling
Plate Number:
AOCL-21
Plate Location:
g5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
55 mg/mL; 140.53 mM
