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GSK 3 Inhibitor IX
Cat. No.:
0225LY-1261
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
GSK 3 Inhibitor IX (6-BIO) acts as a selective, ATP-competitive, and reversible inhibitor of the CDK1-cyclin B complex and GSK-3α/β, with IC50 values of 320 nM for CDK1 and 5 nM for GSK-3α/β.
Synonym:
BIO;GSK 3 IX; 6-BIO; 6-Bromoindirubin-3'-oxime; MLS 2052; 6-bromoindirubin-3-oxime; 667463-62-9; GSK-3 Inhibitor IX; 6BIO; GSK 3 Inhibitor IX; 6-bromoindirubin-3-oxime; 6-BIO; (2'Z,3'E)-6-Bromoindirubin-3'-oxime; GSK 3B Inhibitor IX; 6BIO cpd; (2Z,3E)-6-Bromoindirubin-3'-oxime; GSK 3 IX; 6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol; (2Z,3E)-6'-bromo-2,3'-biindole-2',3(1H,1'H)-dione 3-oxime; (2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
CAS No.:
667463-62-9
Compound CID:
448949
Formula:
C16H10BrN3O2
Formula Weight:
356.17
Specification
Targets&IC50:
GSK-3: 5 nM; CDK1-CyclinB: 0.32 μM; CDK2-CyclinA: 0.30 μM; TYK2: 30 nM; CDK5-p35: 0.08 μM
Relative Density:
1.8 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GSK 3 Inhibitor IX can be used in signaling research to explore the selective inhibition of glycogen synthase kinase-3.
Library Information
Target:
Tyrosine kinases; GSK-3; CDK
Receptor:
CDK; CDK1/CyclinB; CDK2/CyclinA; CDK5/p35; GSK-3; Tyk2
Pathways:
Stem cell regulation; Apoptosis; Tyrosine kinase/adaptors; Cell cycle/Checkpoint; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-17
Plate Location:
b8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
45 mg/mL; 126.34 mM
Ethanol Max Solubility:
21 mg/mL; 58.96 mM
